Published January 1, 2014
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Fructose-coated nanoparticles: a promising drug nanocarrier for triple-negative breast cancer therapy
Creators
- 1. Univ New S Wales, Sch Chem, Ctr Adv Macromol Design, Sydney, NSW 2052, Australia
Description
Fructose transporter GLUT5 is overexpressed in breast cancer cell lines, but not in healthy tissue. Micelles based on fructose, which were found to be low fouling, showed a high uptake by breast cancer cells (MCF-7 and MDA-MB-231 cells), but only negligible uptake by macrophages.
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