Published January 1, 2014
| Version v1
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Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies
Creators
- 1. Middle E Tech Univ, Dept Chem, Fac Arts & Sci, TR-06531 Ankara, Turkey
- 2. Hacettepe Univ, Fac Med, Dept Med Biol, TR-06100 Ankara, Turkey
- 3. Kadir Has Univ, Fac Engn & Nat Sci, Dept Computat Biol & Bioinformat, Istanbul, Turkey
Description
New aryl butenoic acid derivatives have been synthesized by combining hydroxy- or methoxy-substituted phenyl rings as the capping group, with a double bond in the short linker as well as metal binding groups, enoic ester, and salts bearing either methyl or morpholine. These compounds have been shown to possess promising histone deacetylase inhibition activities via in vitro fluorometric assay and molecular docking studies.
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