Published January 1, 2014
| Version v1
Journal article
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The association between Histone 3 Lysine 27 Trimethylation (H3K27me3) and prostate cancer: relationship with clinicopathological parameters
Creators
- 1. Univ Blaise Pascal, Inst Pascal UMR CNRS UBP 6602, Aubiere, France
- 2. Gabriel Montpied Hosp, Dept Anatomopathol, F-63001 Clermont Ferrand, France
- 3. Gabriel Montpied Hosp, Dept Urol, F-63001 Clermont Ferrand, France
Description
Background: It is well established that genetic and epigenetic alterations are common events in prostate cancer, which may lead to aberrant expression of critical genes. The importance of epigenetic mechanisms in prostate cancer carcinogenesis is increasingly evident. In this study, the focus will be on histone modifications and the primary objectives are to map H3K27me3 marks and quantify RAR beta 2, ER alpha, SRC3, RGMA, PGR, and EZH2 gene expressions in prostate cancer tissues compared to normal tissues. In addition, a data analysis was made in connection with the clinicopathological parameters.
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