Published January 1, 2014
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Paal-Knorr Pyrrole Synthesis in Water
- 1. Cukurova Univ, Art & Sci Fac, Dept Chem, TR-01330 Adana, Turkey
Description
Water was a suitable medium for Paal-Knorr pyrrole cyclocondensation. Hexa-2,5-dione was reacted with several aliphatic and aromatic primary amines, affording N-substituted 2,5-dimethyl pyrrole derivatives in good to excellent yields. An efficient, green method using water either as environmentally friendly solvent or catalyst was presented.
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