Yayınlanmış 1 Ocak 2014
| Sürüm v1
Dergi makalesi
Açık
Gene expression changes in aging Zebrafish (Danio rerio) brains are sexually dimorphic
Oluşturanlar
Açıklama
Background: Brain aging is a multi-factorial process due to both genetic and environmental factors. The zebrafish has recently become a popular model organism for examining aging and age-related diseases because as in humans they age gradually and exhibit cognitive decline. Few studies have examined the biological changes in the aging brain that may contribute to these declines and none have examined them within individuals with respect to gender. Our aim was to identify the main genetic pathways associated with zebrafish brain aging across gender. We chose males and females from specific age groups (young, 7.5-8.5 months and old, 31-36 months) based on the progression of cognitive decline in zebrafish. RNA was isolated from individual brains and subjected to microarray and qPCR analysis. Statistical analyses were performed using a two-way ANOVA and the relevant post-hoc tests.
Dosyalar
bib-61c466a3-20b1-4edc-ad24-86706164aae6.txt
Dosyalar
(152 Bytes)
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