Published January 1, 2016
| Version v1
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Quercetin and Cisplatin combined treatment altered cell cycle and mitogen activated protein kinase expressions in malignant mesotelioma cells
- 1. Gebze Tech Univ, Fac Sci, Dept Mol Biol & Genet, TR-41400 Gebze, Kocaeli, Turkey
- 2. Anadolu Univ, Fac Sci, Dept Biol, TR-260470 Eskisehir, Turkey
- 3. Univ Dschang, Fac Sci, Dept Biochem, POB 67, Dschang, Cameroon
Description
Background: Malignant mesothelioma is a locally aggressive and highly lethal neoplasm of pleural, peritoneal and pericardial mesothelial cells without successful therapy. Previously, we reported that Quercetin in combination with Cisplatin inhibits cell proliferation and activates caspase-9 and -3 enzymes in different malignant mesothelioma cell lines. Moreover, Quercetin + Cisplatin lead to accumulation of both SPC111 and SPC212 cell lines in S phase.
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