Published January 1, 2016
| Version v1
Journal article
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A Bio-Acoustic Levitational (BAL) Assembly Method for Engineering of Multilayered, 3D Brain-Like Constructs, Using Human Embryonic Stem Cell Derived Neuro-Progenitors
Creators
- 1. Stanford Univ, Bioacoust MEMS Med BAMM Lab, Dept Radiol, Canary Ctr Early Canc Detect,Sch Med, Palo Alto, CA 94304 USA
Description
A bio-acoustic levitational assembly method for engineering of multilayered, 3D brainlike constructs is presented. Acoustic radiation forces are used to levitate neuro-progenitors derived from human embryonic stem cells in 3D multilayered fibrin tissue constructs. The neuro-progenitor cells are subsequently differentiated in neural cells, resulting in a 3D neuronal construct with inter and intralayer neurite elongations.
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