Published January 1, 2016
| Version v1
Journal article
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Novel Microwave Assisted Synthesis and Antimicrobial Activity of New Quinolone-Hybrids
Creators
- 1. Artvin Coruh Univ, Dept Occupat Hlth & Safety, Fac Med Sci, TR-08000 Artvin, Turkey
- 2. Karadeniz Tech Univ, Macka Vocat Sch, Dept Chem & Chem Proc Technol, Trabzon, Turkey
- 3. Karadeniz Tech Univ, Dept Chem, Trabzon, Turkey
- 4. Recep Tayyip Erdogan Univ, Dept Biol, Fac Sci, Rize, Turkey
Description
Background: Carbo(thio)amid derivatives 4a, 4b were obtained starting from nalidixic acid in three steps. The acidic treatment of compound 4a generated the corresponding 1,3,4-oxadiazole (5), while the compound 4a gave 1,2,4-triazole derivatives 8a, 8b in basic media. The condensation of 4a with ethyl bromoacetate and 4-chlorophenacyl bromide afforded 1,3-oxazolidine, 6 and 1,3-thiazolidine, 7 derivatives. The synthesis of Mannich bases of 9-15 and 17-19 were achieved from the reaction of 1,2,4-triazoles, 8a, 8b and 1,3,4-oxadiazole, 16, with several heterocyclic amines that has biological activity.
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