Published January 1, 2016
| Version v1
Journal article
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A novel fluorescence turn-on coumarin-pyrazolone based monomethine probe for biothiol detection
Creators
- 1. Gazi Univ, Fac Sci, Dept Chem, Tekn Okullar, TR-06500 Ankara, Turkey
- 2. Gazi Univ, Dept Adv Technol, Tekn Okullar, TR-06500 Ankara, Turkey
- 3. Ankara Univ, Fac Med, Dept Med Oncol, TR-06100 Ankara, Turkey
Description
A coumarin-pyrazolone monomethine based turn-on fluorescence ratiometric probe C-3 for selective detection of cysteine (Cys) and glutathione (GSH) is reported. It exhibits OFF-ON states and is more sensitive to GSH in aqueous solution neutral and basic pH. The ON state is due to the inhibition of intramolecular charge transfer (ICT) process between pyrrole and pyrazolone moieties. (C) 2016 Elsevier Ltd. All rights reserved.
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