Published January 1, 2016
| Version v1
Journal article
Open
Synthesis and carbonic anhydrase inhibitory properties of novel chalcone substituted benzenesulfonamides
- 1. Giresun Univ, Tech Sci Vocat Sch, TR-28049 Giresun, Turkey
- 2. Agn Ibrahim Cecen Univ, Dept Pharmaceut Technol, TR-04100 Agri, Turkey
- 3. Agn Ibrahim Cecen Univ, Sci & Art Fac, Dept Chem, TR-04100 Agri, Turkey
- 4. Univ Firenze, Dipartimento Neurofarba, Sez Sci, Polo Sci, Via Ugo Schiff 6, I-50019 Florence, Italy
Description
Carbonic anhydrases (CAs, EC 4.2.1.1) are crucial metalloenzymes involved in many bioprocesses, through catalysis of the reversible hydration/dehydration process of CO2/HCO3-. The inhibition of human CA isoforms I and II with a new series of sulfonamide derivatives incorporating substituted chalcone moieties were studied in this study. All these newly synthesized sulfonamides demonstrated important inhibitory profiles to these CA isoforms with K(1)s in the range of 9.88 to 55.43 nM, making these compounds interesting leads, with potential applications in medicinal chemistry. (C) 2016 Published by Elsevier Ltd.
Files
bib-85b87718-2941-4893-9df8-b547367d7f9b.txt
Files
(226 Bytes)
| Name | Size | Download all |
|---|---|---|
|
md5:67ea419f70d2f9bd135824cfd4604abb
|
226 Bytes | Preview Download |