Published January 1, 2016
| Version v1
Journal article
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Design, Synthesis, and Evaluation of Heat Shock Protein 90 Inhibitors in Human Breast Cancer and Its Metastasis
- 1. Bozok Univ, Fac Arts & Sci, Dept Chem, Yozgat, Turkey
- 2. Cumhuriyet Univ, Div Biochem, Dept Basic Sci, Fac Pharm, Sivas, Turkey
- 3. Ahi Evran Univ, Fac Arts & Sci, Dept Mol Biol & Genet, Kirsehir, Turkey
- 4. Gazi Univ, Fac Arts & Sci, Dept Chem, Ankara, Turkey
Description
Background: Despite development of novel cancer drugs, invasive ductal breast carcinoma and its metastasis are still highly morbid. Therefore, new therapeutic approaches are being developed and Hsp90 is an important target for drug design. For this purpose, a series of benzodiazepine derivatives were designed and synthesized as novel Hsp90 inhibitor.
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