Published January 1, 2016
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Synthesis and anti-proliferative activity of fluoro-substituted chalcones
Creators
- 1. Mersin Univ, Fac Pharm, Dept Pharmaceut Chem, TR-33169 Mersin, Turkey
- 2. Ataturk Univ, Dept Chem, Fac Sci, TR-25240 Erzurum, Turkey
- 3. Mustafa Kemal Univ, Fac Med, Dept Med Biol, TR-31100 Antakya, Turkey
- 4. Mustafa Kemal Univ, Fac Med, Dept Med Microbiol, TR-31100 Antakya, Turkey
Description
A series of novel fluoro-substituted chalcone derivatives have been synthesized. All synthesized compounds were characterized by H-1 nuclear magnetic resonance (NMR), C-13 NMR, and elemental analysis. Their anti-proliferative activities were evaluated against five cancer cells lines, namely, A549, A498, HeLa, A375, and HepG2 using the MTT method. Most of the compounds showed moderate to high activity with IC50 values in the range of 0.029-0.729 mu M. Of all the synthesized compounds, 10 and 19 exhibited the most potent anti-proliferative activities against cancer cells, and 10 was identified as the most promising compound. (C) 2016 Elsevier Ltd. All rights reserved.
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