Yayınlanmış 1 Ocak 2016
| Sürüm v1
Dergi makalesi
Açık
gamma-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3-and 5-component cascades
Oluşturanlar
- 1. Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England
Açıklama
gamma-Carbolines were prepared from pyrido[4,3-b]-5H-indoles via Pd(0)-catalysed, stereo and regioselective allene/uridine allene insertion 3- and 5-component cascades. This versatile reaction sequence gives a range of structurally diverse carboline derivatives and tolerates a broad range of substrates. The power of this approach has been harnessed to produce gamma-carboline based HDAC inhibitors. (C) 2016 Elsevier Ltd. All rights reserved.
Dosyalar
bib-581b07b1-92a1-4434-ae2c-746c1354bfd0.txt
Dosyalar
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