Published January 1, 2016
| Version v1
Journal article
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Frontal delta event-related oscillations relate to frontal volume in mild cognitive impairment and healthy controls
Creators
- 1. IRCCS San Raffaele Pisana, Rome, Italy
- 2. Dokuz Eylul Univ, Dept Neurosci, TR-35340 Izmir, Turkey
- 3. Univ Roma La Sapienza, Dept Physiol & Pharmacol, Lab Neuroimaging, Rome, Italy
- 4. Dokuz Eylul Univ, Sch Med, Dept Radiol, TR-35340 Izmir, Turkey
- 5. Istanbul Kultur Univ, Brain Dynam Cognit & Complex Syst Res Ctr, TR-34156 Istanbul, Turkey
Description
Amnesic mild cognitive impairment (MCI) represents a risk of developing Alzheimer's disease (AD), but not all MCI subjects progress to dementia of AD type. Magnetic resonance imaging (MRI) of cortical and hippocampal atrophy supports early diagnosis of AD in MCI subjects, while frontal event-related oscillations (EROS) at delta frequencies (<4 Hz) are appealing markers for this purpose, as they are both cost-effective and largely available. The present study tested the hypothesis that these EROs reflect cortical frontal neurodegeneration in the continuum between normal and amnesic MCI subjects.
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