Published January 1, 2016
| Version v1
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Metastasis suppressor proteins in cutaneous squamous cell carcinoma
Creators
- 1. Ankara Numune Training & Res Hosp, Dept Pathol, Ankara, Turkey
- 2. Hacettepe Univ, Fac Med, Inst Sci, Dept Plast Surg,Dept Bioengn, Ankara, Turkey
- 3. Kirikkale Univ, Fac Med, Dept Dermatol, Kirikkale, Turkey
- 4. Bilkent Univ, Fac Sci, Dept Mol Biol & Genet, TR-06800 Ankara, Turkey
- 5. Istanbul Medipol Univ, Int Sch Med, Dept Physiol, Istanbul, Turkey
- 6. Kirikkale Univ, Fac Med, Dept Pathol, Kirikkale, Turkey
Description
Cutaneous squamous cell carcinomas (cSCCs) are common human carcinomas. Despite having metastasizing capacities, they usually show less aggressive progression compared to squamous cell carcinoma (SCC) of other organs. Metastasis suppressor proteins (MSPs) are a group of proteins that control and slow-down the metastatic process. In this study, we established the importance of seven well-defined MSPs including NDRG1, NM23-H1, RhoGDI2, E-cadherin, CD82/KAI1, MKK4, and AKAP12 in cSCCs.
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