Published January 1, 2016
| Version v1
Journal article
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Hydrogen Peroxide-Responsive Nanoparticle Reduces Myocardial Ischemia/Reperfusion Injury
Creators
- 1. Gwangju Christian Hosp, Dept Cardiol, Gwangju, South Korea
- 2. Chonbuk Natl Univ, Dept BIN Fus Technol, Jeonju, South Korea
Description
Background-During myocardial ischemia/reperfusion (I/R), a large amount of reactive oxygen species (ROS) is produced. In particular, overproduction of hydrogen peroxide (H2O2) is considered to be a main cause of I/R-mediated tissue damage. We generated novel H2O2-responsive antioxidant polymer nanoparticles (PVAX and HPOX) that are able to target the site of ROS overproduction and attenuate the oxidative stress-associated diseases. In this study, nanoparticles were examined for their therapeutic effect on myocardial I/R injury.
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