Published January 1, 2016 | Version v1
Journal article Open

Flufenamic acid prevents behavioral manifestations of salicylate-induced tinnitus in the rat

  • 1. Gaziantep Univ, Dept Physiol, Fac Med, TR-27310 Gaziantep, Turkey
  • 2. Firat Univ, Fac Vet, Dept Anat, TR-23169 Elazig, Turkey
  • 3. Kirikkale Univ, Dept Med Biol, Fac Med, Kirikkale, Turkey
  • 4. Firat Univ, Dept Neurol, Fac Med, Elazig, Turkey
  • 5. Firat Univ, Dept Plast Reconstruct & Esthet Surg, Fac Med, Elazig, Turkey

Description

Introduction: Tinnitus is defined as a phantom auditory sensation, the perception of sound in the absence of external acoustic stimulation. Given that flufenamic acid (FFA) blocks TRPM2 cation channels, resulting in reduced neuronal excitability, we aimed to investigate whether FFA suppresses the behavioral manifestation of sodium salicylate (SSA)-induced tinnitus in rats.

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