Published January 1, 2016
| Version v1
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Dexamethasone - PAMAM dendrimer conjugates for retinal delivery: preparation, characterization and in vivo evaluation
Creators
- 1. Hacettepe Univ, Dept Pharmaceut Technol, Fac Pharm, TR-06100 Ankara, Turkey
- 2. Bogazici Univ, Dept Chem, Istanbul, Turkey
Description
ObjectiveOcular diseases affecting retina, such as diabetic retinopathy (DR), age-related macular degeneration (AMD) and glaucoma are the major causes of blindness, and their treatment is still a challenge due to the special structure of the eye. The purpose of this study was to prepare a sustained release DEX conjugate formulation with enhanced ocular permeation using poly(amidoamine) (PAMAM) dendrimers and to evaluate the effects of conjugation on DEX release and ocular residence time.
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