Published January 1, 2016
| Version v1
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Facile synthesis of the azocino[4,3-b]indole framework of strychnopivotine and other Strychnos alkaloids
- 1. Namik Kemal Univ, Dept Chem, TR-59030 Tekirdag, Turkey
- 2. Namik Kemal Univ, Dept Chem Technol, TR-59700 Muratli Tekirdag, Turkey
- 3. Hitit Univ, Dept Chem, TR-19030 Corum, Turkey
Description
A new synthetic route to the 1,5-methanoazocino[4,3-b]indole is described. The aim of the present study is to provide a tetracyclic skeleton for the synthesis of pentacyclic Strychnos alkaloids (tubifolidine and strychnopivotine). Starting from a carbazole derivative, the ring closure was achieved by an intramolecular aldol reaction. The final product was obtained in 45% in the overall yield over 7 steps.
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