Yayınlanmış 1 Ocak 2016 | Sürüm v1
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Enantioselective synthesis of 2-amino-4-(nitromethyl)-4H-chromene-3-carbonitriles from 2-iminochromenes

  • 1. Bursa Tech Univ, Dept Chem, TR-16190 Bursa, Turkey
  • 2. Uludag Univ, Dept Chem, Bursa, Turkey

Açıklama

A series of medicinally important 2-amino-4-(nitromethyl)-4H-chromene-3-carbonitriles were synthesized using enantioselective conjugate addition of nitromethane to 2-iminochromenes. The reactions were performed using L8-Cu (II) catalytic system and moderate to good enantioselectivities (62-88%) and yields (66-96%) were obtained.

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