Published January 1, 2020
| Version v1
Journal article
Open
Analysis of the developmental expression of small VCP-interacting protein and its interaction with steroidogenic acute regulatory protein in Leydig cells
- 1. Ankara Yildirim Beyazit Univ, Med Fac, Dept Histol & Embryol, TR-06800 Ankara, Turkey
Description
Small VCP-interacting protein (SVIP) is a 9-kDa protein that is composed of 76 amino acids, and it plays a role in the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recent studies have shown that SVIP is an androgen-responsive protein and its expression is regulated by androgens. Because no data are available regarding the cellular localization and expression of SVIP in the mouse testis, where androgens are highly expressed, immunohistochemistry and western blotting were performed. In the fetal testis, we found that moderate but consistent staining of SVIP is present in the cytoplasm of Leydig cells. In prepubertal and adult life, SVIP remains present in Leydig cells as well as in the cytoplasm of some peritubular and Sertoli cells. From postnatal day 15 onward, SVIP is strongly expressed in the cytoplasm of Leydig cells.
Files
bib-ea0aef0f-1131-4a81-bbb9-c61ac0ffcc3b.txt
Files
(252 Bytes)
| Name | Size | Download all |
|---|---|---|
|
md5:ab2cea26a05ae95684a6622c7b506b40
|
252 Bytes | Preview Download |