Yayınlanmış 1 Ocak 2016
| Sürüm v1
Dergi makalesi
Açık
Predicting Protein-Protein Interactions from the Molecular to the Proteome Level
Oluşturanlar
- 1. Middle E Tech Univ, Grad Sch Informat, Dept Hlth Informat, TR-06800 Ankara, Turkey
Açıklama
Identification of protein protein interactions (PPIs) is at the center of molecular biology considering the unquestionable role of proteins in cells. Combinatorial interactions result in a repertoire of multiple functions; hence, knowledge of PPI and binding regions naturally serve to functional proteomics and drug discovery. Given experimental limitations to find all interactions in a proteome, computational prediction/modeling of protein interactions is a prerequisite to proceed on the way to complete interactions at the proteome level. This review aims to provide a background on PPIs and their types. Computational methods for PPI predictions can use a variety of biological data including sequence-, evolution-, expression-, and structure-based data. Physical and statistical modeling are commonly used to integrate these data and infer PPI predictions. We review and list the state-of-the-art methods, servers, databases, and tools for protein-protein interaction prediction.
Dosyalar
bib-4792f4a9-81fb-490f-9571-b23204957e04.txt
Dosyalar
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