Published January 1, 2016
| Version v1
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Impact of glucocorticoid receptor gene (NR3C1) polymorphisms in Turkish patients with metabolic syndrome
- 1. Istanbul Medipol Univ, Sch Med, Dept Internal Med, Div Endocrinol & Metab, Istanbul, Turkey
- 2. Marmara Univ, Sch Med, Dept Med Biol, Basibuyuk Mah,Maltepe Basibuyuk Yolu Sok 9-1, TR-34854 Istanbul, Turkey
- 3. Namik Kemal Univ, Fac Arts & Sci, Dept Mol Biol, Tekirdag, Turkey
- 4. Zorlu Ctr, Mem Wellness Endocrinol & Metab, Istanbul, Turkey
- 5. Parc 15 Endocrinol & Metab Clin, Istanbul, Turkey
Description
Background The metabolic syndrome (MetS) is characterized by a cluster of metabolic factors, including insulin resistance and type-2 diabetes, abdominal obesity, dyslipidemia, hypertension and microalbuminuria. Impaired glucocorticoid receptor (GR) activity also plays an important role in the etiology of MetS. The objective of our study is to evaluate the effects of GR gene polymorphisms (BclI, N363S, TthIII1 and ER22/23EK) in Turkish patients with MetS.
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