Published January 1, 2016
| Version v1
Journal article
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Association of the OPRM1 and COMT genes' polymorphisms with the efficacy of morphine in Tunisian cancer patients: Impact of the high genetic heterogeneity in Tunisia?
Creators
- 1. CHU Farhat Hached, Lab Cytogenet Genet Mol & Biol Reprod Humaine, Rue Ibn El Jezzar, Sousse 4002, Tunisia
- 2. Fac Med, Lab Biochim Med, F-63000 Clermont Ferrand, France
- 3. Univ Limoges, CHU Limoges, Inserm UMR 850, F-87000 Limoges, France
- 4. CHU Farhat Hached, Serv Carcinol, Sousse 4002, Tunisia
Description
Background. - Genetic causes for inter-individual variability response to opioids are clinical difficulties for treatment efficiency. The aim of the present study was to investigate the possible association of opioid treatment outcome with single nucleotide polymorphisms (SNPs) in the mi.', opioid receptor (OPRM1) and catechol-o-methyltransferase (COMT) genes, in Tunisian cancer pain patients.
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