Regio- and diastereoselective synthesis of trans-dihydrofuran-3-carboxamides by radical addition of 1,3-dicarbonyl compounds to acrylamides using manganese(III) acetate and determination of exact configuration by X-ray crystallography

In this study, we investigated the radical addition of 1,3-dicarbonyl compounds to acrylamide derivatives including phenyl, 2-thienyl and 5-methyl-2-furyl groups mediated by manganese(III) acetate. trans-3-Carboxamide-dihydrofurans were obtained in modarate to good yields, as well as regio- and diastereoselectievly. Structural analyses of these compounds were made by NMR techniques such as HMBC and NOSY spectra. Also, exact configuration and structures of these (7b, 7i and 7j) compounds were determined by X-ray crystallography.