Published January 1, 2016
| Version v1
Journal article
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H3K4 acetylation, H3K9 acetylation and H3K27 methylation in breast tumor molecular subtypes
Creators
- 1. Univ Blaise Pascal, Pascal Inst, CNRS, UMR 6602, F-63177 Aubiere, France
- 2. Univ Auvergne, ERTICA, EA 4677, F-63011 Clermont Ferrand, France
Description
Aim: Here, we investigated how the St Gallen breast molecular subtypes displayed distinct histone H3 profiles. Patients & methods: 192 breast tumors divided into five St Gallen molecular subtypes (luminal A, luminal B HER2-, luminal B HER2+, HER2+ and basal-like) were evaluated for their histone H3 modifications on gene promoters. Results: ANOVA analysis allowed to identify specific H3 signatures according to three groups of genes: hormonal receptor genes (ERS1, ERS2, PGR), genes modifying histones (EZH2, P300, SRC3) and tumor suppressor gene (BRCA1). A similar profile inside high-risk cancers (luminal B [HER2+], HER2+ and basal-like) compared with low-risk cancers including luminal A and luminal B (HER2-) were demonstrated. Conclusion: The H3 modifications might contribute to clarify the differences between breast cancer subtypes.
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