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Published January 1, 2020 | Version v1
Journal article Open

Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation

Creators

  • 1. Univ Edinburgh, MRC, Ctr Reprod Hlth, Queens Med Res Inst, Edinburgh, Midlothian, Scotland
  • 2. Univ Hosp Essen, Dept Otorhinolaryngol, Essen, Germany
  • 3. Jagiellonian Univ, Dept Immunol, Fac Biochem Biophys & Biotechnol, Krakow, Malopolska, Poland
  • 4. Western Norway Univ Appl Sci, Fac Engn & Nat Sci, Dept Biomed Lab Scientist Educ & Chem Engn, Bergen, Hordaland, Norway
  • 5. Radboud Univ Nijmegen, Med Ctr, Dept Radiat Oncol, Radiotherapy & Oncolmmunol Lab, Nijmegen, Gelderland, Netherlands
  • 6. Hacettepe Univ, Canc Inst, Dept Basic Oncol, Ankara, Turkey
  • 7. Univ Lisbon, Fac Med, Inst Med Mol Joao Lobo Antunes, Lisbon, Lisboa, Portugal
  • 8. Univ Hosp Essen, Inst Virol, Essen, Nordrhein Westf, Germany
  • 9. Pasteur Inst, HIV Inflammat & Persistence, Paris, Ile De France, France
  • 10. Univ Belgrade, Dept Mol Oncol, Inst Med Res, Belgrade, Beograd, Serbia
  • 11. Univ Bergen, Dept Clin Sci, Bergen, Hordaland, Norway

Description

Background Myeloid-derived suppressor cells (MDSC) are a functional myeloid cell subset that includes myeloid cells with immune suppressive properties. The presence of MDSC has been reported in the peripheral blood of patients with several malignant and non-malignant diseases. So far, direct comparison of MDSC across different diseases and Centers is hindered by technical pitfalls and a lack of standardized methodology. To overcome this issue, we formed a network through the COST Action Mye-EUNITER () with the goal to standardize and facilitate the comparative analysis of human circulating MDSC in cancer, inflammation and infection. In this manuscript, we present the results of the multicenter study Mye-EUNITER MDSC Monitoring Initiative, that involved 13 laboratories and compared circulating MDSC subsets across multiple diseases, using a common protocol for the isolation, identification and characterization of these cells.

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