NANOSTRUCTURED MATERIALS LOADED WITH IBUPROFEN AND COATED WITH A METHACRYLIC ACID COPOLYMER MATRIX

The synthesis of nanostructured materials (NMs) loaded with Ibuprofen (IBU) was carried out by a modified double emulsion (O/W/W) technique. An enteric coating which was made from the Eudragit L-100 (EL-100) and Eudragit L-30 D-55 (EL-30D-55) copolymers mixture was used as polymeric matrix. Nanostructured materials (NMs) were obtained varying the amounts of surfactant (20-40 mg) and the stirring rates (5600-15000 rpm). The average sizes of the NMs were around 300-800 nm. The best result of the nanostructured materials (NMs) process synthesis was reached with the combination of the copolymer EL-100 and EL-30 D-55. In this sample, the nanoparticles yield and encapsulation efficiency were higher than 40% and the release profiles presented a smaller burst. The release profiles indicated that the matrix used was suitable to prevent the contact of the active principle with the gastric medium and that this device could achieve an efficient release in the intestine.