Published January 1, 2016
| Version v1
Journal article
Open
Effect of microemulsion formulation on biodistribution of Tc-99m-Aprotinin in acute pancreatitis models induced rats
Creators
- 1. Ege Univ, Dept Radiopharm, Fac Pharm, TR-35100 Izmir, Turkey
- 2. Istanbul Medipol Univ, Sch Pharm, Dept Pharmaceut Technol, Istanbul, Turkey
- 3. Ege Univ, Dept Pharmaceut Technol, Fac Pharm, Izmir, Turkey
- 4. Ege Univ, Dept Gastroenterol, Fac Med, Izmir, Turkey
Description
Background: Aprotinin is a monomeric globular polypeptide, which derived from bovine lung tissue and theoretically attractive molecule in ameliorating the effects of acute pancreatitis. Acute pancreatitis is an inflammatory condition of the pancreas that is painful and at times deadly. Over the following two decades Aprotinin therapeutic potential on pancreatitis is proven experimentally, its clinical therapeutic success is limited due to low targeting to pancreas.
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