Bioconjugation of Magnetic Iron Oxide Nanoparticles and Cross-Linked Enzyme Aggregates: Characterization and Comparison of CLEAs and Magnetic CLEAs

Background: The separation of enzymes from the bio-product medium constitutes a significant part of total process cost. Therefore, it is of crucial importance that the separation processes for enzymes be specially developed. In this study, the advantages of cross-linked enzyme aggregates (CLEAs) and magnetic iron oxide nanoparticles (MIONPs) have been combined in magnetic CLEAs matrix.