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Published January 1, 2017 | Version v1
Journal article Open

R202Q/M694V as novel MEFV gene mutations in chronic periodontitis and familial Mediterranean fever

Creators

  • 1. Univ Suleyman Demirel, Fac Dent, Dept Periodontol, Isparta, Turkey
  • 2. Univ Suleyman Demirel, Dept Med Genet, Fac Med, Isparta, Turkey
  • 3. Univ Suleyman Demirel, Div Rheumatol, Dept Internal Med, Isparta, Turkey
  • 4. Univ Suleyman Demirel, Dept Med Biochem, Fac Med, Isparta, Turkey
  • 5. Univ Suleyman Demirel, Dept Biostat & Med Informat, Fac Med, Isparta, Turkey

Description

Background and Objective: Familial Mediterranean fever (FMF) and chronic periodontitis are inflammatory diseases leading to an increase in the number of inflammasomes. To date, no published studies have reported on mutations in the Mediterranean fever (MEFV) gene in patients with chronic periodontitis, although the roles of MEFV gene mutations in FMF and FMF-associated amyloidosis (FMF-A) are well known. Therefore, the aim of this study was to evaluate the frequencies of MEFV gene mutations and serum amyloid A (SAA) and high-sensitivity C-reactive protein (hs-CRP) levels in patients with chronic periodontitis, FMF and FMF-A.

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