Published January 1, 2017
| Version v1
Journal article
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Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds
Creators
- 1. Karadeniz Tech Univ, Dept Chem, TR-61080 Trabzon, Turkey
- 2. Karadeniz Tech Univ, Dept Chem & Chem Proc Technol, TR-61080 Trabzon, Turkey
- 3. Artvin Coruh Univ, Dept Occupat Hlth & Safety, Artvin, Turkey
- 4. Recep Tayyip Erdogan Univ, Dept Biol, Rize, Turkey
Description
The hydrazide 5, that was obtained from -1-(4-fluorophenyl) piperazine (1), was converted to the cor-responding carbothioamides 6a-c by the reaction with alkyl(aryl) isothiocyanates. The synthesis of conazole analogs 10a-f was performed via the intermediary of triazoles 7a-c. The condensation of triazoles 7a-c with -several -heterocyclic amines in the presence of formalde-hyde afforded the corresponding N-aminoalkylated tria-zoles 11-14. The effect of different catalysts and solvents on conventional and microwave (MW)-prompted reac-tions was examined. The synthesized compounds were screened for their antimicrobial activities.
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