Published January 1, 2020 | Version v1
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Sex-specific associations of TCF7L2 variants with fasting glucose, type 2 diabetes and coronary heart disease among Turkish adults

  • 1. Istanbul Univ, Aziz Sancar Inst Expt Med, Dept Genet, TR-34080 Istanbul, Turkey
  • 2. Istanbul Univ, Cerrahpasa Fac Med, Dept Cardiol, Istanbul, Turkey
  • 3. Istanbul Univ, Cerrahpasa Fac Med, Dept Publ Hlth, Istanbul, Turkey

Description

Objective: TCF7L2 is a repressor and transactivator of genes, and its variants are strongly associated with diabetes. This study aimed to evaluate the sex-specific relationship between the most common TCF7L2 gene variants (-98368G>T, rs12255372 and -47833C>T, rs7903146) with diabetes and coronary heart disease in Turkish Adult Risk Factor (TARF) Study.

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