Published January 1, 2017
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The effect of sodium hyaluronate-chondroitin sulfate combined solution on cartilage formation in osteochondral defects of the rabbit knee: an experimental study
Creators
- 1. Adiyaman Univ, Fac Med, Dept Orthopaed & Traumatol, TR-02100 Adiyaman, Turkey
- 2. Firat Univ, Fac Med, Dept Orthopaed & Traumatol, Elazig, Turkey
- 3. Firat Univ, Fac Med, Dept Pathol, Elazig, Turkey
- 4. Kirikkale Univ, Fac Med, Dept Orthopaed & Traumatol, Kirikkale, Turkey
Description
Objective: In focal cartilage lesions, multipotent mesenchymal stem cells in bone marrow are aimed to be moved into the defect area using subchondral drilling or microfracture method. However, repaired tissue insufficiently fills the defect area or cannot meet natural hyaline tissue functions, due to fibrous structure. We investigated the effect of a combined solution of sodium hyaluronate + chondroitin sulfate (HA+CS) administered intra-articularly after subchondral drilling on newly formed cartilage in rabbits with focal osteochondral defects.
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