Published January 1, 2017 | Version v1
Journal article Open

Evaluation of the line probe assay for the rapid detection of bacterial meningitis pathogens in cerebrospinal fluid samples from children

  • 1. Univ Washington, Seattle Childrens Hosp, Seattle, WA 98195 USA
  • 2. Anadolu Med Ctr, Kocaeli, Turkey
  • 3. Marmara Univ, Fac Med, Dept Pediat, Div Pediat Infect Dis, Istanbul, Turkey

Description

Background: The aim of this study is to compare the diagnostic performance of the line probe assay (LPA) with conventional multiplex polymerase chain reaction (PCR) for Streptococcus pneumoniae as well as real-time PCR for Neisseria meningitidis and Haemophilus influenzae type b (Hib) in cerebrospinal fluid (CSF) samples from children during the multicenter national surveillance of bacterial meningitis between the years 2006 and 2009 in Turkey.

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