Published January 1, 2017
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Reaction of (S)-homoserine lactone with Grignard reagents: synthesis of amino-keto-alcohols and beta-amino acid derivatives
- 1. Ataturk Univ, Dept Chem, Fac Sci, TR-25240 Erzurum, Turkey
Description
The ring-opening reaction of homoserine lactone with phenylmagnesium bromides was systematically examined. A reliable method to achieve beta-amino acid precursors was developed by tuning the reaction conditions to favor mono-addition to the carbonyl moiety of the lactone. (C) 2017 Elsevier Ltd. All rights reserved.
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