Published January 1, 2017
| Version v1
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Structure-Based Hybridization, Conventional and Microwave Irradiated Synthesis, Biological Evaluation and Molecular Docking Studies of New Compounds Derived from Thiomorpholin
Creators
- 1. Giresun Univ, Bulancak Kadir Karabas Sch Appl Sci, Dept Crop Prod & Technol, TR-28000 Giresun, Turkey
- 2. Gebze Tech Univ, Fac Sci, Dept Chem, TR-41400 Kocaeli, Turkey
- 3. Karadeniz Tech Univ, Dept Biol, TR-61080 Trabzon, Turkey
- 4. Recep Tayyip Erdogan Univ, Dept Biol, TR-53100 Rize, Turkey
- 5. Karadeniz Tech Univ, Dept Chem, TR-61080 Trabzon, Turkey
Description
Background: The amine 2 obtained via two steps starting from thiomorpholine was converted into the corresponding 1,3-thiazole (4), arylmethileneamino (5a- d) and hydrazide (7) derivatives using conventional and also microwave techniques. The synthesis of 1,3,4-oxadiazole (8), arylidenenhydrazide (9a-c) and carbothioamides (10a,b) was performed with the treatment of 7 with CS2, suitable amines and suitable isothiocyanates, respectively.
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