Published January 1, 2017
| Version v1
Journal article
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Segmental duplications and evolutionary acquisition of UV damage response in the SPATA31 gene family of primates and humans
Creators
- 1. Max Planck Inst Evolut Biol, August Thienemann Str 2, D-24306 Plon, Germany
- 2. SUNY Buffalo, Dept Biol Sci, Buffalo, NY 14260 USA
- 3. Swiss Inst Allergy & Asthma Res SIAF, CH-7270 Davos, Switzerland
Description
Background: Segmental duplications are an abundant source for novel gene functions and evolutionary adaptations. This mechanism of generating novelty was very active during the evolution of primates particularly in the human lineage. Here, we characterize the evolution and function of the SPATA31 gene family (former designation FAM75A), which was previously shown to be among the gene families with the strongest signal of positive selection in hominoids. The mouse homologue for this gene family is a single copy gene expressed during spermatogenesis.
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