Published January 1, 2020
| Version v1
Journal article
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Response Assessment With Molecular Characterization of Circulating Tumor Cells and Plasma MicroRNA Profiling in Patients With Locally Advanced Breast Cancer During Neoadjuvant Chemotherapy
Creators
- 1. Marmara Univ, Sch Med, Dept Med Biol, Maltepe Basibuyuk Yolu Sok 9-1, TR-34854 Istanbul, Turkey
- 2. Umraniye Educ Res Hosp, Dept Med Oncol, Istanbul, Turkey
- 3. Marmara Univ, Sch Med, Dept Gen Surg, Pendik Istanbul, Turkey
- 4. Acibadem Univ, Dept Biostat & Med Informat, Istanbul, Turkey
- 5. Marmara Univ, Sch Med, Dept Med Oncol, Pendik Istanbul, Turkey
Description
Peripheral blood samples from 36 patients with locally advanced breast cancer who had undergone neoadjuvant chemotherapy were collected for circulating tumor cell (CTC) and plasma microRNA (miR) analysis. Pretreatment CTC and ALDH1 positivity (P = .0245) correlated, with miR-146b-5p and miR-199a-5p accompanied by CTC positivity. CTC and miR profiling of serial samples during neoadjuvant chemotherapy appears to be a very useful in predicting cure and clinical course.
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