Published January 1, 2017
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Synthesis of Novel Pyrazolines, Their Boron-Fluorine Complexes, and Investigation of Antibacterial, Antioxidant, and Enzyme Inhibition Activities
Creators
- 1. Karadeniz Tech Univ, Dept Chem, Fac Sci, TR-61080 Trabzon, Turkey
- 2. Recep Tayyip Erdogan Univ, Dept Biol, Fac Arts & Sci, Rize, Turkey
- 3. Karadeniz Tech Univ, Dept Biochem, Fac Pharm, Trabzon, Turkey
Description
3,5-disubstituted-2-pyrazoline derivatives (4-6), their boron-fluorine complexes (boron (3-(2'-aminophenyl), 5-(2'-/3'-/4'-pyridyl) pyrazoline, BOAPPY) (7-9) and boron 1,2'-diazaflavone complex (BODAF) (11) were synthesized starting from azachalcones (1-3) to diazaflavone (10), respectively. Biological evaluation of compounds 4-9 and 11 showed remarkable antioxidant, antibacterial, and acetylcholinesterase and tyrosinase enzyme inhibition activities. All newly synthesized compounds 4-9 and 11 showed respectable antibacterial effect with minimum inhibitory concentrations in the range of 4.7-150mg/mL.
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