Yayınlanmış 1 Ocak 2017 | Sürüm v1
Dergi makalesi Açık

CT120: A New Potential Target for c-Myc in Head and Neck Cancers

  • 1. Istanbul Univ, Cerrahpasa Med Fac, Dept Med Biol, Istanbul, Turkey

Açıklama

Background: CT120 is a universally expressed protein with seven transmembrane domains. It functions in cell proliferation, survival and apoptosis by activating Raf/MEK/ERK and PI3K/Akt signaling pathways. Evidence suggests that CT120 plays important roles in lung carcinogenesis and oncogenic pathway activation. c-Myc is an important transcription factor modulating cell progression, apoptosis and cellular transformation. Previous studies have shown that MYC gene is amplified in many types of cancer including head and neck squamous cell carcinoma (HNSCC). Myc can regulate expression of many genes by binding to E-boxes. The aim of this study was to investigate the relationship between c-Myc protein and CT120 gene.

Dosyalar

bib-1ea1958a-edda-4818-b414-c6b85af5db1b.txt

Dosyalar (156 Bytes)

Ad Boyut Hepisini indir
md5:4a2414beff67212eb30cf06b65ea71a9
156 Bytes Ön İzleme İndir