Yayınlanmış 1 Ocak 2017
| Sürüm v1
Dergi makalesi
Açık
Alteration of protein localization and intracellular calcium content due to connexin26 D50A and A88V mutations
Oluşturanlar
- 1. Izmir Inst Technol, Dept Mol Biol & Genet, Rm D206, TR-35430 Izmir, Turkey
Açıklama
Introduction: Connexins (Cx) play essential roles in cellular homeostasis by forming gap junctions and non-junctional hemichannels. In vitro characterization of Cx26 mutations causing keratitis-ichthyosis-deafness (KID) syndrome, were shown to form leaky hemichannels. The molecular/cellular mechanisms affected by aberrant hemichannels have recently been elucidated. Here, we further wanted to characterize Cx26 KID syndrome mutations, D50A and A88V, which were shown to form aberrant hemichannels and remained unaddressed in the literature.
Dosyalar
bib-88488823-fd9f-48c8-ba85-aebbe4a649db.txt
Dosyalar
(212 Bytes)
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md5:b321c4321021a30b6dd778b71690f104
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212 Bytes | Ön İzleme İndir |