Published January 1, 2017
| Version v1
Journal article
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Zn phthalocyanine conjugation to H2-ul aptamer for HER2-targeted breast cancer photodynamic therapy: Design, optimization and properties
Creators
- 1. Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Kocaeli, Turkey
- 2. Sabanci Univ, Nanotechnol Res & Applicat Ctr, TR-34956 Istanbul, Turkey
Description
Tetrasulfonated Zn phthalocyanine was conjugated to a ssDNA aptamer moiety to produce a HER2 targeted photosensitizer. The tetraconjugate obtained was subjected to purification and the monoconjugate was successfully isolated, purified and characterized. This monoconjugate retained the ability to bind to HER2 as well as the potency to generate singlet oxygen.
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