Published January 1, 2017
| Version v1
Journal article
Open
Association between chronic hepatitis B virus infection and HLA-DP gene polymorphisms in the Turkish population
Creators
- 1. Cukurova Univ, Fac Med, Dept Gastroenterol, TR-01330 Adana, Turkey
- 2. Cukurova Univ, Arts & Sci Fac, Dept Chem, Adana, Turkey
- 3. Cukurova Univ, Fac Med, Dept Biostat, Adana, Turkey
Description
Aim: Hepatitis B virus (HBV) affects approximately 360 million people worldwide. 10-15% of patients with chronic HBV develop liver cirrhosis (LC), liver failure and hepatocellular carcinoma (HCC). Chronic HBV infection or HBV clearance is influenced by both viral and host factors. In genome-wide association studies (GWAS), the human leukocyte antigen (HLA) gene polymorphisms rs3077 and rs9277535 were identified to be associated with chronic hepatitis B. HLA genes have been linked to immune response to infectious agents. Genetic variants in HLA genes influence HLA mRNA expression which might also affect antigen presentation. We evaluated the association between HLA gene polymorphisms and the risk for persistent HBV infection.
Files
bib-0b4649af-98a1-4d75-a51a-6eed9bf15583.txt
Files
(244 Bytes)
| Name | Size | Download all |
|---|---|---|
|
md5:eb1b9b4debfb92505801b5f6d04e7b0f
|
244 Bytes | Preview Download |