Yayınlanmış 1 Ocak 2017
| Sürüm v1
Dergi makalesi
Açık
Association between chronic hepatitis B virus infection and HLA-DP gene polymorphisms in the Turkish population
Oluşturanlar
- 1. Cukurova Univ, Fac Med, Dept Gastroenterol, TR-01330 Adana, Turkey
- 2. Cukurova Univ, Arts & Sci Fac, Dept Chem, Adana, Turkey
- 3. Cukurova Univ, Fac Med, Dept Biostat, Adana, Turkey
Açıklama
Aim: Hepatitis B virus (HBV) affects approximately 360 million people worldwide. 10-15% of patients with chronic HBV develop liver cirrhosis (LC), liver failure and hepatocellular carcinoma (HCC). Chronic HBV infection or HBV clearance is influenced by both viral and host factors. In genome-wide association studies (GWAS), the human leukocyte antigen (HLA) gene polymorphisms rs3077 and rs9277535 were identified to be associated with chronic hepatitis B. HLA genes have been linked to immune response to infectious agents. Genetic variants in HLA genes influence HLA mRNA expression which might also affect antigen presentation. We evaluated the association between HLA gene polymorphisms and the risk for persistent HBV infection.
Dosyalar
bib-0b4649af-98a1-4d75-a51a-6eed9bf15583.txt
Dosyalar
(244 Bytes)
| Ad | Boyut | Hepisini indir |
|---|---|---|
|
md5:eb1b9b4debfb92505801b5f6d04e7b0f
|
244 Bytes | Ön İzleme İndir |