Published January 1, 2020
| Version v1
Journal article
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Neuroinflammation Mediators are Reduced in Sera of Parkinson's Disease Patients with Mild Cognitive Impairment
Creators
- 1. Demiroglu Bilim Univ, Fac Med, Dept Physiol, Istanbul, Turkey
- 2. Istanbul Univ, Aziz Sancar Inst Expt Med, Dept Neurosci, Istanbul, Turkey
- 3. Istanbul Univ, Neuroimaging Unit, Hulusi Behcet Life Sci Res Lab, Istanbul, Turkey
- 4. Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey
- 5. Bogazici Univ, Biomed Engn Inst, Istanbul, Turkey
Description
Introduction: Cognitive impairment is common in Parkinson's disease (PD) and PD patients with mild cognitive impairment (PD-MCI) are at increased risk of developing Parkinson's disease dementia (PDD). Reliable biomarkers are required for objective identification of cognitive decline in PD. In this pilot study, serum levels of well-known mediators of neuroinflammation were measured in PD patients with or without MCI to find out the involvement of neuroinflammation and microglial activation in PD-MCI.
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