Published January 1, 2017
| Version v1
Journal article
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Estrogen-like and tissue-selective effects of 7-methoxycoumarin from Ficus umbellata (Moraceae): an in vitro and in vivo study
Creators
- 1. Univ Cote Azur, Inst Chem Nice, Fac Sci, UMR CNRS 7272, Valrose Pk, Nice 2, France
- 2. Hudson Inst Med Res, Clayton, Vic 3168, Australia
- 3. Univ Maroua, Higher Teachers Training Coll, Dept Life & Earth Sci, POB 55, Maroua, Cameroon
- 4. Univ Fed Santa Catarina, Hlth Sci Ctr, Dept Pharmaceut Sci, CEP, BR-88040900 Florianopolis, SC, Brazil
- 5. Univ Johannesburg, Fac Sci, Dept Appl Chem, ZA-2028 Doornfontein, South Africa
Description
Background: Ficus umbellata is a medicinal plant previously shown to endow estrogenic properties. Its major component was isolated and characterized as 7-methoxycoumarin (MC). Noteworthy, coumarins and the respective active metabolite 7-hydroxycoumarin analogs have shown aromatase inhibitory activity, which is of particular interest in the treatment of estrogen-dependent cancers. The present work aimed at evaluating the estrogenic/antiestrogenic effects of MC in vitro and in vivo.
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