Published January 1, 2017
| Version v1
Journal article
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Liver 5-HT7 receptors: A novel regulator target of fibrosis and inflammation-induced chronic liver injury in vivo and in vitro
Creators
- 1. Ataturk Univ, Fac Pharm, Dept Pharmacol, TR-25240 Erzurum, Turkey
- 2. Ataturk Univ, Fac Med, Dept Pharmacol, TR-25240 Erzurum, Turkey
- 3. Ataturk Univ, Fac Vet, Dept Pharmacol & Toxicol, TR-25240 Erzurum, Turkey
- 4. Ataturk Univ, Fac Pharm, Dept Biochem, TR-25240 Erzurum, Turkey
- 5. Ataturk Univ, Fac Med, Dept Histol & Embryol, TR-25240 Erzurum, Turkey
Description
Background and aim: Hepatocellular cancer (HCC) is the sixth most common cancer and liver fibrosis is strongly associated with HCC. Treatment options are limited, and preventive strategies should be developed. An important step in the beginning of liver fibrosis is a strong inflammatory response. 5-HT7 is the last recognized member of the serotonin receptor family and is expressed in both central nerve system and peripheral system and have a lot of functions like learning, memory, smooth muscular relaxation, in the control of circadian rhythms and thermoregulation, pain and migraine, schizophrenia, anxiety, cognitive disturbances, and even inflammation.
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