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Published January 1, 2017 | Version v1
Journal article Open

Development of HPLC Methods for Individual Determination of 20 Active Pharmaceutical Ingredients for Ussing-Chamber Studies

Creators

  • 1. Inonu Univ, Fac Pharm, Dept Pharmaceut Technol, TR-44210 Malatya, Turkey
  • 2. Hacettepe Univ, Dept Analyt Chem, Fac Pharm, TR-06100 Ankara, Turkey
  • 3. Hacettepe Univ, Dept Pharmaceut Technol, Fac Pharm, TR-06100 Ankara, Turkey

Description

Background: The aim of this study was to develop HPLC methods for individual determination of 20 active pharmaceutical ingredients (amoxicillin sodium, antipyrine, atenolol, caffeine, carbamazepine, cimetidine, enalapril, furosemide, hydrochlorothiazide, ibuprofen, ketoprofen, metoprolol tartrate, methyldopa, naproxen sodium, pindolol, piroxicam, propranolol HCl, ranitidine, theophylline, and verapamil HCl) to be used for determination of their intestinal permeabilities across Ussing-Chamber.

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