Published January 1, 2017
| Version v1
Journal article
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Synthesis of Novel Benzothiazole-Piperazine Derivatives and Their Biological Evaluation as Acetylcholinesterase Inhibitors and Cytotoxic Agents
Creators
- 1. Yeditepe Univ, Fac Pharm, Dept Pharmaceut Chem, TR-34755 Istanbul, Turkey
- 2. Eastern Mediterranean Univ, Fac Pharm, Dept Pharmaceut Chem, Famagusta, Northern Cyprus, Turkey
- 3. Middle East Tech Univ, Grad Sch Informat, Bioinformat Dept, Ankara, Turkey
- 4. Martin Luther Univ Halle Wittenberg, Inst Pharm, Med Chem Dept, Halle, Saale, Germany
Description
Objective and Method: A new series of benzothiazole-piperazine derivatives was synthesized and a complete chemical characterization of the novel compounds was provided. In vitro cytotoxic activities were screened against colorectal (HCT-116), breast (MCF-7) and hepatocellular (Huh7) cancer cell lines by Sulforhodamine B assay.
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