Yayınlanmış 1 Ocak 2017
| Sürüm v1
Dergi makalesi
Açık
Enantioselective synthesis of new chiral 2-aziridinyl phosphonates and studies of their biological activities
Oluşturanlar
- 1. Middle East Tech Univ, Dept Chem, TR-06800 Ankara, Turkey
- 2. Canakkale Onsekiz Mart Univ, Dept Chem Engn, TR-17100 Canakkale, Turkey
- 3. Ankara Univ, Dept Pharmaceut Microbiol, TR-06100 Ankara, Turkey
- 4. Dokuz Eylul Univ, Dept Phys, TR-35160 Izmir, Turkey
Açıklama
A new series of chiral aziridinyl phosphonates has been synthesized and evaluated for antibacterial and antifungal activities. For the synthesis, a Gabriel-Cromwell reaction was used to form aziridinyl phosphonates in 52-83% yield. In order to evaluate antibacterial and antifungal activities, MIC values were measured. Although most of the compounds showed insignificant activity, two of them provided low to moderate antifungal activity. (C) 2017 Elsevier Ltd. All rights reserved.
Dosyalar
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Dosyalar
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